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时间性MASLD与2型糖尿病,心血管疾病和死亡率的关联
Eugene Han1, Kyung-Do Han2, Yong-Ho Lee3
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
持续的代谢功能障碍与脂肪性肝病 (MASLD) 相关,显著增加2型糖尿病的风险. 在糖尿病患者中,MASLD还会增加心血管疾病和死亡风险.
科学领域:
- 代谢健康和肝脏疾病
- 心血管流行病学心血管流行病学
- 糖尿病研究 糖尿病研究
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 了解MASLD的动态变化及其对代谢和心血管结果的影响至关重要.
研究的目的:
- 调查MASLD状态的变化与患2型糖尿病 (T2DM) 的风险之间的关联.
- 评估MASLD变化对心血管疾病 (CVD) 和预先存在T2DM的个体的死亡率的影响.
主要方法:
- 对20岁或以上的韩国国民健康保险服务数据的分析.
- 按脂肪肝指数 (FLI) ≥60定义的MASLD,在2年内跟踪变化.
- 分类为从未,事件,回归和持久的MASLD组.
主要成果:
- 持久性MASLD显示发生T2DM的风险最高 (HR=5.28).
- 事件和回归的MASLD也增加了T2DM风险 (HR分别为3.30和2.87).
- 在T2DM患者中,持续的MASLD增加了心力衰竭 (HR=1.28),心肌梗塞 (HR=1.15),中风 (HR=1.14) 和死亡率 (HR=1.11) 的风险.
结论:
- 持久性MASLD是T2DM事件的一个重要风险因素.
- 包括事件和回归病例在内的MASLD状态的变化与T2DM,CVD和死亡率的风险增加有关.
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