对口服维生素D补充剂的混合即时和延迟过敏:一个病例报告
Andrew Ridge1,2, Nick Cooling3, Bastian Seidel4,3
1School of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, TAS, 7000, Australia. a.ridge@utas.edu.au.
Journal of medical case reports
|July 15, 2025
概括
对维生素D补充剂的过敏反应很少发生,但有可能发生. 本案例报告详细介绍了一位可能患有维生素D过敏症的患者的成功脱敏计划,使其能够安全补充.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 过敏和临床免疫学
背景情况:
- 维生素D缺乏是一个全球性的健康问题,特别普遍存在于澳大利亚等高度地区的人口中.
- 维生素D在骨健康和免疫系统调节中起着至关重要的作用.
- 虽然维生素D补充在澳大利亚很常见,但不良反应很少见.
研究的目的:
- 报告一种对补充维生素D过敏的罕见病例.
- 调查维生素D不耐受症中涉及的潜在过敏机制.
- 为了评估对维生素D过敏管理的脱敏方案的有效性.
主要方法:
- 一名53岁的女性在服用维生素D补充剂后经历了胃肠道困扰,喘恶化和皮疹.
- 诊断工作包括过敏转诊,免疫球蛋白水平评估和挑测试.
- 一个使用修改的澳大利亚协议的脱敏计划在18周内启动.
主要成果:
- 该患者被诊断为可能患有维生素D过敏症,涉及免疫球蛋白E介导和T细胞介导的途径.
- 尽管皮肤测试呈阴性,但挑测试和Naranjo评分支持过敏诊断.
- 在脱敏后,患者可以容忍每天1000 IU维生素D的剂量.
结论:
- 这一案例突出了对补充维生素D的罕见但可信的过敏反应.
- 对维生素D过敏患者而言,监督性脱敏可以是一个可行的策略,防止与缺乏相关的并发症.
- 当患者表现出对维生素D的不良反应而没有其他明确的沉物时,考虑过敏原因很重要.
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