通过结合性染色体和自身染色体标记,改进了表观遗传年龄预测模型
Zhong Wan1, Peter Henneman2, Huub C J Hoefsloot3
1Molecular and Cellular Epigenetics, Swammerdam Institute for Life Sciences, University of Amsterdam, Room C2.106, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
Epigenetics & chromatin
|July 15, 2025
概括
这项研究表明,将X染色体DNA甲基化标记物与自身染色体标记物的结合显著提高了生物年龄预测的准确性. 新的模型,使用DNA甲基化 (DNAm) 在性染色体和自体上,与现有的方法具有竞争力.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 基因组学就是基因组学.
- 生物遗传学 生物遗传学
背景情况:
- 表观遗传DNA甲基化 (DNAm) 改变是可靠的生物年龄预测.
- 目前的模型主要使用自身体DNAm标记物.
- 纳入性别染色体DNAm标记被探索以提高预测的准确性.
研究的目的:
- 评估将性别染色体DNAm标记物整合到现有的基于自体DNAm的年龄预测模型中的可行性.
- 提高生物年龄预测的准确性和稳定性.
- 为了评估Y染色体DNAm标记物的预测值.
主要方法:
- 随机森林回归 (RFR) 用于构建年龄预测模型.
- 使用了来自人类全血和毛样本的公开可用的DNAm Infinium 450K微阵列数据.
- 模型通过交叉验证使用根-平均平方误差 (RMSE) 和平均绝对偏差 (MAD) 进行了评估.
主要成果:
- 结合性染色体DNAm标记物的模型显示出不同的性能;Y染色体标记物没有改善最佳模型.
- 一个将特定的X染色体DNAm标记物与六个自身染色体标记物相结合的缩小模型实现了高精度 (RMSE: 2.54年,MAD: 1.89年).
- 四个X染色体DNAm标记 (cg27064949,cg04532200,cg01882566,cg25140188) 与时间学年龄有很强的相关性.
结论:
- 结合性染色体和自身染色体DNAm标记可以创建高度准确的年龄预测模型.
- 这种方法为仅使用自身体DNAm标记物的模型提供了有竞争力的替代方案.
- 这些发现推动了结合表观遗传标记在衰老和法医研究中的应用.
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