免疫炎症指数和骨质疏松症之间的关联:系统性审查和元分析
Bihui Bai1,2, Xingwen Xie3, Yongyu Yue1
1Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
European journal of medical research
|July 15, 2025
概括
这一系统性审查发现,像中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 这样的免疫炎症指数与骨质疏松症 (OP) 的风险增加有显著关联. 这些标记可能有助于OP的早期识别和预防策略.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 生物统计学 生物统计学
背景情况:
- 骨质疏松症 (OP) 对健康造成重大负担,炎症标志物显示出诊断和预后效用.
- 免疫-炎症指数和OP风险之间的确切关系仍然不完全理解,需要进一步调查.
研究的目的:
- 系统地审查和元分析免疫炎症指数与骨质疏松症 (OP) 风险之间的关联.
- 确定与OP相关的关键免疫炎症标志物,并探索影响这种关系的因素.
主要方法:
- 在PubMed,科学网络,Embase和Cochrane图书馆进行了全面的文献搜索,截至2025年2月20日.
- 来自24项研究 (8个队列,16个病例控制) 的数据,涉及397525名受试者和11904例病例,使用几率比率 (OR) 和标准化平均差异 (SMD) 进行了分析.
- 使用Review Manager 5.4和STATA 18.0进行了统计分析,并进行了敏感性和子组分析以评估稳定性和异质性.
主要成果:
- 增加的中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR) 和全身免疫炎症指数 (SII) 与增加的OP风险 (ORs从1.05到2.34) 显著相关.
- 与非OP人群相比,OP患者的NLR,PLR,单细胞与淋巴细胞比率 (MLR) 和SII水平显著更高 (SMD范围从0.25到0.71).
- 小组分析表明,地理区域和年龄是影响这些指数与OP之间的关联的重要因素.
结论:
- 免疫-炎症指数,包括NLR,PLR,MLR和SII,与骨质疏松症的风险增加有显著联系.
- 这些标志物有可能用于早期识别高风险OP的个体,从而促进及时的预防干预.
- 建议进行进一步的前性多中心研究,以验证这些发现,并巩固免疫-炎症指数在OP管理中的作用.
更多相关视频
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
381
11:52Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
Published on: January 27, 2023
3.5K
相关概念视频
01:29Bone Disorders
4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
01:28Inflammatory Response
7.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
7.9K
01:31Osteoclasts in Bone Remodeling
3.2K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.2K