压力与败血症患者28天死亡率之间的关联:基于MIMIC-IV数据库的回顾性研究
Yan Zhu1, Jin-Yu Lei1, Jie Zou2
1Department of Emergency and Critical Care, Shanghai Changzheng Hospital of Naval Medical University, No.415 of Fengyang Road, Huangpu District, Shanghai, 200003, China.
European journal of medical research
|July 15, 2025
概括
压力显著增加了败血症患者的28天死亡率. 早期预防策略至关重要,特别是在高风险人群中,以改善压力的败血症患者的治疗结果.
科学领域:
- 临界护理医学 临界护理医学
- 伤口护理 伤口护理
- 流行病学 流行病学
背景情况:
- 压力在败血症患者中代表着重大的临床挑战.
- 了解它们对死亡率的影响对于患者管理至关重要.
研究的目的:
- 调查压力和败血症患者28天死亡率之间的关联.
- 为了确定风险因素和受压力影响的患者子组.
主要方法:
- 利用了MIMIC-IV v3.0数据库对20,280名败血症患者的数据.
- 采用单变量,多变量和考克斯的比例危险分析.
- 进行了卡普兰-梅尔生存曲线和子组分析.
主要成果:
- 在20,280名患者中,有880人患有压力.
- 压力是28天死亡率的重要预测因素 (p=0.002).
- 患有压力的败血症患者的28天死亡风险比为1.30.
结论:
- 压力与败血症患者28天死亡率的增加独立相关.
- 预防工作应针对年轻,男性和伴随性疾病 (糖尿病,脏病) 患者,其SOFA分数较高.
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