人类发展,不平等,以及它们与29个国家的大脑结构的关联
Vicente Medel1, Luz M Alliende2, Richard Bethlehem3,4
1Latin American Brain Health Institute (BrainLat), https://ror.org/0326knt82Universidad Adolfo Ibáñez, Santiago, Chile.
概括
国家一级的发展和不平等影响健康成年人的大脑结构. 较高的发育与较大的海马体和皮质表面积相关,而更大的不平等与较小的海马体和较薄的皮质有关.
科学领域:
- 神经科学是一个神经科学.
- 社会学 社会学 社会学
- 全球健康 全球健康
背景情况:
- 宏观社会和环境因素,如国家发展和不平等,与大脑疾病有关.
- 这些系统性环境因素与大脑结构之间的确切关系尚不清楚.
研究的目的:
- 研究一个国家的发展水平与不平等之间的关联以及健康成年人的大脑结构.
主要方法:
- 进行了横截面元回归分析.
- 来自145个磁共振成像 (MRI) 研究的数据,包括来自29个国家的7962名健康成年人.
- 基于T1的脑成像数据与国家一级的发展和不平等指标相比进行了分析.
主要成果:
- 人类更高的发育与更大的海马和扩大的全球皮质表面积有关,特别是在额头区域.
- 增加的国家不平等与较小的海马体积和大脑上皮层厚度的减少相关.
结论:
- 宏观经济条件反映在一个国家人口的大脑结构中.
- 这些发现可能有助于解释全球大脑疾病发病率的变化.
- 承认跨国大脑结构的变化对于开发全球化的精准医学工具至关重要.
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