在蒙特卡洛生物物理3D多细胞模型中细胞内放射性核素分布的影响,用于向的α疗法

Victor Levrague1, Mario Alcocer-Ávila2, Sarah Leilla Otmani1

  • 1Université Grenoble Alpes, CNRS, Grenoble INP, LPSC-IN2P3, Grenoble, France.

Medical physics
|July 16, 2025
PubMed
概括

对细胞内α-发射体分布的准确建模对于预测向α疗法 (TAT) 疗效至关重要,特别是在小瘤中. 了解放射性核素的分布影响细胞存活率和瘤控制概率.

相关概念视频

Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.4K
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.2K
Isotopes and Radioisotopes01:28

Isotopes and Radioisotopes

In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
10.5K