英国抗精神病药物处方的25年趋势:挑战和机遇
Hannah Newman1,2, David Branford1, Richard Laugharne1,3
1Peninsula School of Medicine, University of Plymouth, Plymouth, UK.
BJPsych open
|July 16, 2025
概括
英格兰的抗精神病药物处方每年每1000人增加4.27,显著增加. 这种由口服抗精神病药物的使用驱动的趋势,引发了人们对超出批准指示范围的潜在过度使用的担忧.
科学领域:
- 药物监测和公共卫生
- 药物使用流行病学 药物使用流行病学
背景情况:
- 抗精神病药主要用于精神病障碍.
- 人们担心抗精神病药物可能过度使用,用于治疗不适合的疾病.
研究的目的:
- 分析1998年至2022年英格兰人均社区处方和抗精神病药物成本的趋势.
- 为了在25年期间识别处方模式的变化.
主要方法:
- 使用了从1998年至2022年的OpenPrescribing数据库数据.
- 包括抗精神病药物和depot注射的英国国家表格子类别.
- 计算每年处方增加和每1000人平均年增幅.
- 雇佣散射图和斯皮尔曼相关性用于趋势分析.
- 估计的年度药物总成本.
主要成果:
- 观察到抗精神病药物处方的显著增加,平均每年每1000人4.27.
- 在人均时间和抗精神病药物处方之间存在强烈的正相关性 (斯皮尔曼的rho=0.995,P≤0.001).
- 处方的增加主要归因于口服抗精神病药物的使用.
- 抗精神病药物成本波动,增加到2011年,下降到2016年,并从2020-2022年再次上升.
结论:
- 这项研究表明,英国抗精神病药物处方的上升趋势令人担忧.
- 这种增长的潜在驱动因素可能包括非标签或非许可处方.
- 调查结果强调需要对临床实践进行审查,并进一步研究处方模式和适应症.
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