甲状腺功能在正常范围内与血糖控制和心血管风险因素在1型糖尿病中的关联
Mariana Lourenço1, Ana Rita Leite2,3, Patrícia Ferreira2,4
1Faculty of Medicine of University of Porto, Porto, Portugal.
Expert review of endocrinology & metabolism
|July 16, 2025
概括
在正常范围内的甲状腺激素水平会影响1型糖尿病 (T1D) 的心脏代谢健康. 即使是微妙的变化也会影响T1D患者的血糖控制和心血管风险因素.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 心血管健康 心血管健康
背景情况:
- 甲状腺激素 (TH) 的变化,即使在正常范围内,也会影响心脏代谢健康.
- 在1型糖尿病 (T1D) 管理中,优化血糖控制和心血管风险至关重要.
- 了解TH在T1D中的作用对于预防并发症至关重要.
研究的目的:
- 调查T1D成年人的正常范围的甲状腺激素水平和心脏代谢参数之间的关联.
- 探索TSH,ft4和ft3的变化如何与血糖控制和心血管风险因素相关.
主要方法:
- 对296名成年T1D患者进行横截面研究.
- 排除甲状腺刺激激素 (TSH) 或自由甲状腺素 (fT4) 在参考范围之外的个体.
- 线性回归和受限立方线用于分析TH与心脏代谢/血糖参数之间的关联.
主要成果:
- 中等范围的TSH水平与改善的血糖控制相关 (在范围内的时间更高,在范围以上的时间更低).
- fT4显示出与腰围和BMI的负相关性;fT3和fT3/fT4比率显示出与腰围和BMI的负相关性.
- 估计的淋巴膜过率 (eGFR) 与TSH和ft4负相关,与ft3和ft3/ft4.4正相关.
结论:
- 通常范围的甲状腺激素变化与T1D的血糖控制有关.
- 甲状腺激素水平在甲状腺激素水平范围内的甲状腺激素水平会影响1型糖尿病患者的心血管风险因素.
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