PREDAC-FluB:预测季节性B型流感病毒的抗原集群,使用基于嵌入式卷积神经网络的蛋白质语言模型
Wenping Xie1,2, Jingze Liu3,4, Chuan Wang2,4,5
1College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Wuhan 430074, Hubei Province, China.
Briefings in bioinformatics
|July 16, 2025
概括
预测B型流感病毒抗原变异对于疫苗菌株选择至关重要. 新型深度学习框架PREDAC-FluB准确识别抗原群并预测病毒演变,有助于开发有效的流感疫苗.
科学领域:
- 病毒学 病毒学
- 计算生物学 计算生物学
- 免疫学 免疫学 免疫学
背景情况:
- 流感病毒,特别是B型流感病毒,由于其快速的抗原变异,对全球健康构成重大风险.
- 预测流感抗原漂移的现有方法对于B型流感病毒是不够的,阻碍了有效的疫苗菌株选择.
- 准确预测抗原变化对于开发具有广泛保护性和有效的流感疫苗至关重要.
研究的目的:
- 开发和验证一种新的计算框架PREDAC-FluB,用于预测B型流感病毒的抗原变异.
- 在B型流感血统 (B/Victoria和B/Yamagata) 中识别不同的抗原集群.
- 建立一个强大的工具,以帮助选择最佳流感疫苗菌株.
主要方法:
- 一个混合深度学习框架 (PREDAC-FluB),集成卷积神经网络 (CNN) 来从HA1序列中提取空间特征.
- 多模式序列表示,将ESM-2嵌入式与六个物理化学描述符 (ESM2-7特征) 结合起来.
- 基于UMAP指导的聚类,用于识别使用B型流感病毒数据的抗原聚类.
主要成果:
- PREDAC-FluB成功地将B/维多利亚血统分为9个,B/亚马加塔血统分为3个抗原群.
- 该框架在预测抗原变异方面表现优于传统机器学习方法.
- 实现了高预测准确度,AUROC值在验证时达到0.9961,在B/维多利亚病毒的独立测试集上达到0.9856.
结论:
- PREDAC-FluB是一种强大而准确的工具,用于B型流感病毒的抗原计算.
- 该框架有效地捕捉了抗原变异,为推未来流感疫苗菌株提供了一个有希望的辅助方法.
- 这种方法解决了流感监测和疫苗开发的关键未满足需求.
更多相关视频
13:12Quantitative Analyses of all Influenza Type A Viral Hemagglutinins and Neuraminidases using Universal Antibodies in Simple Slot Blot Assays
Published on: April 4, 2011
18.4K
12:18Expression of Functional Recombinant Hemagglutinin and Neuraminidase Proteins from the Novel H7N9 Influenza Virus Using the Baculovirus Expression System
Published on: November 6, 2013
24.3K
相关概念视频
Leaky Scanning
5.2K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.2K
Conjugated Proteins
18.6K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.6K
