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Updated: Sep 15, 2025

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PIEZO1 过度表达在遗传性出血性长膜炎 动脉静脉形

Hyojin Park1,2, Sungwoon Lee1, Jessica Furtado1,2

  • 1Cardiovascular Research Center, Department of Internal Medicine (H.P., S.L., J.F., M.A.S., L.H.Y., A.E.), Yale University School of Medicine, New Haven, CT.

Circulation
|July 16, 2025
PubMed
概括

在遗传性出血端膜炎中,阻断PIEZO1通过正常化activin受体类激酶1 (ALK1) 缺乏细胞的信号传递来减少动脉静脉形 (AVM). 这表明PIEZO1是血管疾病的治疗点.

关键词:
其他类型人类的PIEZO1蛋白鼠标中的PIEZO1蛋白动脉静脉形机械传导,细胞血脉切开症,遗传性出血症

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