评估 LV 收缩性 识别具有保留喷射分数的人群,有不良心力衰竭结果的风险
Sam Straw1, Oliver I Brown1, Charlotte A Cole2
1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom. (S.S., O.I.B., M.C.-R., M.F.P., M.D., T.A.S., E.L., K.K.W., M.T.K., R.M.C., J.G.).
Circulation. Cardiovascular imaging
|July 16, 2025
概括
心脏收缩率指数 (CCI) 有效地预测心力衰竭 (HF) 风险,即使在患有正常左心室喷射率 (LVEF) 的患者中也是如此. 这种简单的,非侵入性的措施为HF群体提供了宝贵的预后见解.
科学领域:
- 心脏病学 心脏病学
- 临床研究 临床研究
- 生物医学工程 生物医学工程
背景情况:
- 左心室喷射分数 (LVEF) 是标准的心力衰竭 (HF) 评估工具,但受到负载依赖的限制.
- 需要额外的工具来对正常LVEF的患者进行风险分层.
- 研究了心脏收缩率指数 (CCI),即缩血压与左心室末缩体积的比率.
研究的目的:
- 评估心脏收缩率指数 (CCI) 的预后值.
- 评估CCI与亚临床心肌功能障碍和HF事件的关联.
- 确定CCI是否可以对患有正常LVEF的患者进行风险分层.
主要方法:
- 对新诊断的HF患者进行前性观察队列研究.
- 对英国生物库数据的分析,分析了CCI,心肌功能障碍和HF事件之间的关联.
- 分层为具有减少喷射率 (HFrEF) 的HF和具有保留喷射率 (HFpEF) 的HF组.
主要成果:
- 在HF患者中,CCI下降与死亡率增加相关 (P<0.001).
- 在HFpEF中,低于中位数的CCI表明死亡风险更高 (17.3/100患者年),而高于中位数的CCI (8.8/100患者年;P<0.001).
- 在没有HF和正常LVEF的个体中,中位数以下的CCI与发生HF风险增加33%有关 (aHR,1.33;P=0.043).
结论:
- CCI是一种简单的,非侵入性的,相对独立于后负载的方法,用于分层HF风险,特别是在正常的LVEF群体中.
- CCI的简单性使其可以应用于现有的临床试验数据,并在未来的随机对照试验中使用.
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