建立一个评估基础设施,以捕捉临床和翻译科学奖中心的过程和进展
Maggie Padek1, Dinesh Pal Mudaranthakam2, Sam Pepper2
1Frontiers Clinical and Translational Science Institute, University of Kansas Medical Center, Kansas City, KS, USA.
Journal of clinical and translational science
|July 16, 2025
概括
边界临床和翻译科学研究所通过新的评估平台改善了管理. 这个系统标准化了措施,简化了流程,并提高了数据透明度,以获得更好的结果.
科学领域:
- 临床和翻译科学 临床和翻译科学
- 医疗保健服务研究 医疗服务研究
- 项目评估 项目评估
背景情况:
- 对研究机构来说,有效的管理能力至关重要.
- 现有的评估基础设施往往缺乏全面性,效率和透明度.
- 标准化措施和简化数据收集是关键的挑战.
研究的目的:
- 改造边界临床和翻译科学研究所的评估基础设施.
- 开发一个全面,高效和透明的系统来展示研究产出和结果.
- 减少调查人员的数据输入负担,并整合持续改进过程.
主要方法:
- 利用以利用为中心的评估框架来开发逻辑模型并确定适当的指标.
- 在REDCap内建立了一个评估数据平台,整合了多个方案领域的9个项目.
- 实现了一个使用REDCap动态SQL查询字段和外部模块进行定制通信和数据捕获的会员模式.
- 集成数据同步到实时仪表板,用于跟踪输出和结果.
主要成果:
- 自平台于2022年秋季推出以来,提高了工作流效率和简化了持续改进沟通.
- 跨程序领域的标准化措施,减少调查人员的数据输入负担.
- 实现了对输出和结果的全面,高效和透明的展示.
结论:
- 开发的评估平台显著提高了管理能力和运营效率.
- 该平台可以作为其他寻求建立强大的评估计划的研究中心的可复制模型.
- 整合REDCap和会员模式在数据管理和流程改进方面被证明是有效的.
相关概念视频
01:11Clinical Trials: Overview
3.4K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.4K
01:16Clinical Trials
8.6K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
8.6K
01:15Nursing Evaluation
3.6K
The evaluation stage signals the end of the nursing process. The nurse gathers evaluative data to assess whether or not the patient has attained the expected results. Whereas the nurse collects data in the nursing assessment to identify the patient's health concerns, the evaluation stage data determines if the indicated health issues are resolved. Evaluative data collection includes two sections: the data acquired to evaluate patient outcomes and the time criteria for data collection.
3.6K
01:12Statistical Software for Data Analysis and Clinical Trials
796
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
796
01:28Preclinical Development: Overview
4.9K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.9K
02:07Improving Translational Accuracy
11.9K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.9K