评估血液和尿路标记物以预测自发性尿道结石通道
Ziv Savin1, Kavita Gupta1, Dara Lundon1
1Department of Urology, Icahn School of Medicine at Mount Sinai New York, NY, USA.
American journal of clinical and experimental urology
|July 16, 2025
概括
常规的血液和尿液测试不能可靠地预测自发性尿道结石通道 (SSP). 石头的大小和位置是预测石头通道结果的更好的指标.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 实验室医学 实验室医学
背景情况:
- 预测自发性尿路结石通道 (SSP) 对于患者管理至关重要.
- 之前对血液和尿液标记物用于SSP预测的研究已经产生了关于其可靠性的不确定的结果.
研究的目的:
- 评估常见的血液和尿液实验室测试对自发性尿道结石通道的预测潜力.
- 为了确定像白细胞计数 (WBC),中性粒细胞与淋巴细胞比率 (NLR) 和肌素水平这样的标志物是否可以预测SSP.
主要方法:
- 对165名尿路结石小于10毫米的患者进行前性观察性研究.
- 收集血液和尿液标记物,包括WBC,NLR,肌素和尿液白细胞雌激酶.
- 使用单变量,多变量和ROC曲线分析分析数据,以评估与SSP的标记器关联.
主要成果:
- 53%的患者发生了自发的尿路结石通道 (SSP).
- 在任何测试的血液或尿液标记物和SSP之间没有发现显著的关联.
- 较小的石头大小和远端尿路位置是SSP的重要预测因素.
结论:
- 常规的血液和尿液实验室检测不是自发尿道结石通道的可靠预测指标.
- 这些标记物对SSP预测名录的贡献可能是可以忽略不计的.
- 临床重点应该转向其他因素,如石材特性,用于预测SSP.
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