在不同度下, хлорфенапир对毒性的作用
Jia Li1, Dongquan Zhao1, Cheng Li1
1Department of Emergency, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, No. 336 Dongfeng Road, Zhuhui District, Hengyang, Hunan 421001, China.
Toxicology research
|July 16, 2025
概括
хлорфенапир在老鼠和人类细胞中引起损伤. 高度会导致更严重的影响,包括细胞死亡和线粒体功能障碍.
科学领域:
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 细胞生物学 细胞生物学
背景情况:
- хлорфенапир是一种具有潜在毒性作用的杀虫剂.
- 毒性是一个重要的健康问题,需要进一步调查.
研究的目的:
- 为了研究二对Wistar大鼠脏和人类脏-2 (HK-2) 细胞的毒作用.
- 为了评估二的剂量依赖性毒性.
主要方法:
- 在体内研究中,使用Wistar大鼠对血素和素 (HE),马森染色和免疫组织化学 (IHC) 进行了实验.
- 在体外研究中使用HK-2细胞与流细胞计和西方斑点 (WB).
- 评估脏组织损伤,纤维化标志物,线粒体膜潜力 (MMP),亡,活性氧物种 (ROS) 和特定蛋白质表达.
主要成果:
- 在大鼠中,Chlorfenapyr诱导轻度脏组织损伤和增加纤维化标志物,剂量为30 mg/kg.
- 在实验室中, хлорфенапир提高了ROS,导致线粒体功能障碍,并在HK-2细胞中诱导了亡.
- 在体内和体外模型中观察到剂量依赖性毒性增加,线粒体标记物 (COX IV,TOM20,PGC-1α) 和亡调节剂 (BAX,Bcl-2) 的显著变化.
结论:
- 在动物模型和人类细胞中, хлорфенапир表现出显著的毒性.
- 费纳皮尔的毒性作用取决于度.
- 线粒体功能障碍和亡在二诱导的脏毒性中起着关键作用.
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