年轻人的神经认知与没有糖尿病前期
medRxiv : the preprint server for health sciences
|July 16, 2025
概括
患有糖尿病前期的年轻人表现出认知障碍,包括空间工作记忆缺陷,独立于肥胖. 早期发现和治疗胰岛素敏感性受损对于预防认知能力下降至关重要.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 2型糖尿病和糖尿病前期与老年人认知障碍有关.
- 机制,特别是在年轻人中和独立于肥胖,仍然不清楚.
- 由于胰岛素敏感性,年轻人患有糖尿病前期认知障碍的风险尚不清楚.
研究的目的:
- 研究糖尿病前期和超重/肥胖年轻人的认知之间的关系.
- 为了确定认知障碍是否独立于脂肪.
- 探索中央胰岛素敏感性在糖尿病前期相关认知变化中的作用.
主要方法:
- 对69名超重/肥胖年轻人的横截面研究.
- 通过口服葡萄糖耐受性测试,分类为糖尿病前期 (T2D+前) 和正常血糖控制 (T2D-) 组.
- 综合性认知测试,代谢测量和评估鼻内胰岛素对大脑活动和连接性的影响.
主要成果:
- 与对照人群相比,患有糖尿病前期的年轻人显示智商显著降低,工作记忆,反应时间和视觉空间处理表现较差.
- 在控制智商后,空间工作记忆缺陷仍然存在.
- 胰岛素敏感性与处理速度有负相关性,并且与涉及空间工作记忆的大脑区域的功能连接有关.
结论:
- 糖尿病前期与全球认知障碍和年轻人的特定空间工作记忆缺陷有关,独立于肥胖.
- 虽然中央胰岛素敏感性与认知有关,但它不能完全解释糖尿病前期的认知影响.
- 研究结果表明,对胰岛素敏感性受损的早期干预对患有糖尿病前期的年轻人至关重要,以减轻认知风险.
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