一项针对MUC1疫苗的多中心试点研究,针对目前和前吸烟者,他们面临高风险的肺癌
medRxiv : the preprint server for health sciences
|July 16, 2025
概括
对高风险肺癌患者来说,MUC1疫苗是安全的和可行的,但观察到高水平的免疫抑制. 需要进一步的研究来克服吸烟引起的免疫抑制,以有效地预防肺癌的免疫.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 吸烟是肺癌的主要原因,戒烟并不能消除风险.
- 在肺癌和前恶性病变中观察到异常的Mucin (MUC) 1糖蛋白表达.
- 研究MUC1疫苗以阻止高风险个体瘤发育至关重要.
研究的目的:
- 评估MUC1疫苗在现有和前重度吸烟者中的免疫性和安全性.
- 评估MUC1疫苗对免疫抑制标记物的影响,如髓质衍生抑制细胞 (MDSC) 和调节性T细胞.
主要方法:
- 一个多中心试验,涉及50名现任和前重度吸烟者 (≥30包年),具有特定的CT胸部发现.
- 在0,2和10周服用MUC1疫苗.
- 疫苗接种前和随访点对抗MUC1IgG标位,MDSC和调控性T细胞的评估.
主要成果:
- 在完成研究的45名参与者中,MUC1疫苗耐受性良好.
- 观察到总体免疫反应率为13.3% (抗MUC1IgG标位≥2倍以上).
- 在目前和前吸烟者中检测到高循环水平的免疫抑制MDSC.
结论:
- 在肺癌风险较高的人群中,MUC1疫苗的使用是可行的和安全的.
- 研究队列表现出显著的免疫抑制,类似于晚期肺癌患者.
- 克服吸烟引起的免疫抑制对于成功的肺癌免疫预防策略至关重要.
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