在自闭症谱系障碍中肠道微生物群的组成和遗传学分析:一项比较研究
Fangtao Xiang1, Mei Zhang1, Xin Wei1
1Leshan Normal University, Sichuan Provincial Key Laboratory of Philosophy and Social Sciences for Language Intelligence in Special Education, Leshan, China.
Frontiers in psychiatry
|July 16, 2025
概括
患有自闭症谱系障碍 (ASD) 的儿童表现出改变的肠道细菌,导致短链脂肪酸 (SCFA) 的变化. 这种肠脑轴不平衡可能会使ASD的肠道和神经症状恶化.
科学领域:
- 微生物组研究的研究.
- 神经胃肠病学 神经胃肠病学
- 代谢学 代谢学 代谢学
背景情况:
- 自闭症谱系障碍 (ASD) 与胃肠道 (GI) 问题有关,肠道微生物群和短链脂肪酸 (SCFA) 通过肠-大脑轴发挥潜在作用.
- 在ASD中,肠道微生物和SCFA之间的确切关系是有争议的,需要综合分析来理解这些联系.
- 这项研究研究了肠道微生物群的组成及其对ASD儿童SCFA产生的影响,与对照组相比,探索了与肠道肠道症状和神经发育结果的联系.
研究的目的:
- 分析患有自闭症谱系障碍 (ASD) 的儿童的肠道微生物组合.
- 评估肠道微生物群对ASD中短链脂肪酸 (SCFA) 生产的影响.
- 探索肠道微生物特征,SCFA产生,胃肠道症状和ASD神经发育结果之间的关系.
主要方法:
- 16S rRNA基因测序用于分析38名患有自闭症儿童和33名对照儿童 (4-12岁) 的便样本.
- 使用QIIME2,MetagenomeSeq和LEfSe进行了微生物多样性,分类学和预测功能的评估.
- 短链脂肪酸 (SCFA) 产量是从分类组合和微生物丰富性分析推断出来的.
主要成果:
- 与对照组相比,患有自闭症的儿童表现出微生物α多样性的减少和明显的β多样性的减少.
- 自闭症样本显示了Firmicutes的枯竭和Bacteroidetes的丰富.
- 预测的代谢途径表明在ASD中更低的丁酸盐和更高的酸盐/酸盐生产,与微生物连接性降低.
结论:
- 在ASD中的微生物失生症似乎改变了SCFA概况,可能会增加丁酸盐和酸盐水平.
- 这些微生物和代谢变化可能会导致ASD的胃肠道和神经症状.
- 研究结果支持针对微生物群的干预措施,如益生菌,作为ASD的潜在治疗策略.
相关概念视频
01:19Autism Spectrum Disorder
340
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
340
01:23Anatomy of the Intestines
74.1K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
74.1K