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Updated: Sep 15, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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低RAF丰度对EGFR-ERK信号传输的系统层次后果

Sung Hyun Lee, Paul J Myers, Kevin S Brown

    bioRxiv : the preprint server for biology
    |July 16, 2025
    PubMed
    概括

    癌细胞中低RAF激酶的丰富性会产生信号瓶,影响ERK通路激活和瘤性RAS突变效应. 这项研究使用计算模型量化了这些效应,揭示了一个常见但未被研究的信号系统.

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