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Updated: Sep 15, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

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在无序结合基因中,连接器的长度和组成调节了多价值蛋白相互作用开关的激烈性和可逆性

Kiran Sankar Chatterjee1, Maria A Martinez-Yamout1, H Jane Dyson1

  • 1Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037.

bioRxiv : the preprint server for biology
|July 16, 2025
PubMed
概括

本质上有障碍的蛋白质调节细胞对低氧 (低氧) 的反应. 这项研究揭示了缺氧诱导因子1-alpha (HIF-1α) 的突变如何微调其与协同激活剂的相互作用,影响缺氧开关.

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