贾斯:一种强大的表示学习方法,用于对不完整的多omics数据进行增强分析.
Jenna L Ballard1, Zongyu Dai2, Li Shen3
1Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, 3700 Hamilton Walk, Philadelphia, 19104, PA, USA.
bioRxiv : the preprint server for biology
|July 16, 2025
概括
对于不完整的多omics数据的新方法JASMINE通过保留独特和共享的生物信息来有效地学习表示. 这种方法可以提高下游任务的性能,而无需进行特定任务的培训.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 基因组学就是基因组学.
背景情况:
- 综合性多学科分析提供了深刻的生物学见解,但面临着诸如高维度和缺失数据等挑战.
- 目前对不完整的多学科数据的方法有限,无法充分利用所有信息或避免有偏见的表示.
研究的目的:
- 为不完整的多omics数据开发一种新的自我监督的表示学习方法.
- 保持模式特定和联合信息,同时提高样本相似性.
- 通过使用多omics数据集,提高各种下游任务的性能.
主要方法:
- 提出了JASMINE,一个自我监督的学习框架,用于不完整的多学科数据.
- 专注于保留模式特定和联合特征表示.
- 在已学习的嵌入中增强了样本相似性的结构.
主要成果:
- 在两个不同的不完整的多omics数据集上,JASMINE在多个任务中实现了卓越的性能.
- 该方法有效地从数据中学习了缺失模式的表示.
- 证明了保存独特和共享生物信息的能力.
结论:
- JASMINE提供了一个强大的解决方案,用于分析不完整的多omics数据.
- 该方法通过有效整合各种数据类型来增强生物洞察力.
- 为生物信息学中的表示学习提供了一种多功能和高效的方法.
相关概念视频
Mass Spectrometry: Complex Analysis
898
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
898
RNA-seq
10.4K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases.
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
10.4K
Mass Spectrometry: Overview
6.0K
Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electrospray ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave...
6.0K
Multi-input and Multi-variable systems
150
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence...
In the absence...
150
Multi-species Conserved Sequences
4.3K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.3K
¹H NMR: Interpreting Distorted and Overlapping Signals
1.1K
Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
1.1K


