阴茎状细胞癌中的组织因子表达:HPV独立疾病的标志物
bioRxiv : the preprint server for biology
|July 16, 2025
概括
组织因子 (TF) 表达在HPV阴性阴茎状细胞癌 (PSCC) 中较高,并与异常p53相关. TROP2与HPV阳性PSCC和淋巴血管侵入有关.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 生物标志物发现发现
背景情况:
- 阴茎状细胞癌 (PSCC) 是一种罕见的恶性瘤.
- 了解PSCC的分子驱动因素,特别是与HPV相关的与HPV独立的亚型,对于向治疗至关重要.
- 组织因子 (TF),Nectin-4和TROP2是各种癌症中的潜在生物标志物.
研究的目的:
- 为了评估PSCC中的组织因子 (TF),Nectin-4和TROP2的表达.
- 为了将TF,Nectin-4和TROP2表达与HPV状态,p53表达和临床病理特征相关联.
- 研究这些标记物作为PSCC亚型和预后生物标记物的潜力.
主要方法:
- 从33名PSCC患者的瘤中构建组织微阵列 (TMA).
- 免疫组织化学 (IHC) 染色用于TF,Nectin-4和TROP2.
- 染色强度 (H分) 和阳性细胞百分比的评估.
- 与HPV/p16状态,p53表达,瘤等级,转移,入侵,无复发生存 (RFS) 和癌症特异性生存 (CSS) 的相关性分析.
主要成果:
- 在HPV阴性和p16阴性PSCC瘤 (膜和细胞质) 中,TF表达显著更高.
- 异常的p53表达在具有更高TF染色的瘤中更频繁.
- TROP2染色显示与阳性p16状态和淋巴血管入侵 (LVI) 有关.
- 在TF,TROP2或Nectin-4与RFS或CSS之间没有发现显著的关联,这可能是由于样本规模较小.
结论:
- TF可以作为HPV独立的,p53-异常PSCC的生物标志物.
- TROP2可能与HPV相关的PSCC有关,并可能与LVI等侵略性特征相关.
- 需要对更大的队列进行进一步的研究,以确认PSCC中这些标志物的预后价值.
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