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在体感皮质中,PV 内神经元的动态招募是由经验依赖的可塑性诱导的

Baruc Campos¹, Iris Marmouset-de la Taille^1,2,3, William Zeiger¹

¹Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

bioRxiv : the preprint server for biology

|July 16, 2025

概括

经验依赖的可塑性重塑大脑电路. 在体感皮质中的帕瓦尔胺 (PV) 内神经元在胡须修剪期间改变其活动,可能限制大脑地图的变化.

科学领域:

神经科学是一个神经科学.
神经可塑性神经可塑性
身体感官系统身体感官系统

背景情况:

适应性电路可塑性对于学习和感官处理等大脑功能至关重要.
在体感管皮层 (S1BF) 中,体验依赖的可塑性涉及重新绘制胡须表示.
控制这种可塑性的精确电路机制,特别是涉及PV内部神经元,尚未完全理解.

研究的目的:

为了研究S1BF在胡须修剪期间在PV细胞中传感唤起的活动如何发生变化.
确定光伏细胞活动在调节与胡须可塑性相关的皮质重绘中的作用.

主要方法:

在S1BF中的PV细胞在胡须修剪之前,期间和之后的长度 in vivo 两光子成像.
化学基因操纵PV细胞活动,以评估对神经反应的因果关系.
分析PV细胞和其他神经元类型 (金字塔细胞,SST内部神经元) 的胡须调和选择性.

主要成果:

在基线时,PV细胞对胡须偏移表现出距离依赖的反应.
胡须修剪诱导了对被剥夺的桶中被遗留的胡须反应的PV细胞的招募,这在重新生长时逆转了.
增加的PV细胞活动抑制了局部金字塔细胞,PV细胞和索马托斯坦素 (SST) 内神经元中的感官唤起的反应.

结论:

在经验依赖的可塑性过程中,光伏电池在空间分布和调整中发生动态变化.
在胡须修剪期间增加的PV细胞活动可能会限制成年S1BF的皮质重绘.
这些发现强调了内部神经元活动在调节感官皮质可塑性方面的关键作用.

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