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Updated: Sep 15, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Published on: February 21, 2018

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克隆性造血中的MYD88突变促进炎症和造血干细胞扩张

Jennifer Yeung, Sophia Y Philbrook, Emma Uible

    bioRxiv : the preprint server for biology
    |July 16, 2025
    PubMed
    概括

    MYD88突变通过激活血液构造干细胞和原生细胞 (HSPCs) 中的先天免疫通路来驱动不确定潜力的克隆性血液构造 (CHIP). 这导致炎症和血液病,扩大了CHIP的理解,超出了常见的突变.

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