基因调节,表型记忆和在波动的环境中进行选择
bioRxiv : the preprint server for biology
|July 16, 2025
概括
细菌使用基因调节网络来适应不断变化的环境. 这项研究揭示了环境波动如何选择支持或反对基因调节,这对细菌进化和适应有影响.
科学领域:
- 微生物生态学 微生物生态学
- 进化生物学 进化生物学
- 系统生物学 系统生物学
背景情况:
- 基因调节网络 (GRNs) 对于细菌适应环境变化至关重要.
- 了解塑造GRNs的进化压力仍然是一个挑战.
研究的目的:
- 研究基因调控在波动的代谢环境中的进化成本和益处.
- 确定有利于或不利于基因调节的特定环境条件.
- 阐明GRN中感知和控制的进化动态.
主要方法:
- 利用条形码测序来随着时间的推移监测细菌菌株的频率.
- 具有改变基因表达动态的竞争细菌菌株,以量化选择.
- 独立地扰乱了环境传感和基因表达控制机制.
主要成果:
- 发现基因表达水平可以进化以创建表型记忆,缓解滞后阶段并改善人口增长.
- 在GRNs中识别了环境感知和表达控制之间的标志性表达.
- 证明完整的感知机制在波动的条件下增强了基因表达的进化调整.
结论:
- 环境波动对基因调节网络施加明显的选择性压力.
- 感知和控制之间的表观相互作用对GRN进化至关重要.
- 这项工作为理解在动态环境中的GRN演变提供了一个新的框架.
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