相关实验视频

Updated: Sep 15, 2025

Polarized Translocation of Fluorescent Proteins in Xenopus Ectoderm in Response to Wnt Signaling
06:55

Polarized Translocation of Fluorescent Proteins in Xenopus Ectoderm in Response to Wnt Signaling

Published on: May 26, 2011

10.9K

多元素的机械敏感定位突出了其在脊椎动物形态发生和平面细胞极性中的功能

Satheeja Santhi Velayudhan, Chih-Wen Chu, Keiji Itoh

    bioRxiv : the preprint server for biology
    |July 16, 2025
    PubMed
    概括

    多元素是细胞极性中的关键蛋白质,对Xenopus胚胎发育至关重要. 它的定位和运动揭示了一种取决于张力的机制,控制组织形态发生和神经管闭合.

    更多相关视频

    A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro09:50

    A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro

    Published on: August 27, 2015

    8.3K
    En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos08:57

    En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

    Published on: July 27, 2022

    1.8K

    相关概念视频

    Mechanism of Lamellipodia Formation01:31

    Mechanism of Lamellipodia Formation

    Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
    2.8K
    Cell Polarization by Rho Proteins01:21

    Cell Polarization by Rho Proteins

    Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
    2.8K
    Tension Response at Adherens Junctions01:26

    Tension Response at Adherens Junctions

    The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
    α-Catenin as a Mechanosensory Protein
    The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
    2.9K
    Cytoskeletal Coordination in Cell Migration01:32

    Cytoskeletal Coordination in Cell Migration

    A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
    4.9K
    Desmosomes01:05

    Desmosomes

    The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
    5.7K
    Role of Myosin in Cell Migration01:18

    Role of Myosin in Cell Migration

    Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
    Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
    2.4K