相关实验视频

Updated: Sep 15, 2025

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells
05:02

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Published on: February 4, 2021

3.4K

可溶性E-cadherin在炎症性乳腺癌中驱动大脑转移

Xiaoding Hu, Yun Xiong, Emilly S Villodre

    bioRxiv : the preprint server for biology
    |July 16, 2025
    PubMed
    概括

    在转移性炎症性乳腺癌 (IBC) 中,可溶性E-cadherin (sEcad) 的升高促进了通过激活瘤细胞生存途径和改变大脑微环境来促进大脑转移. 用抗体准CXCR2轴可能会减少转移并改善存活率.

    更多相关视频

    Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis07:43

    Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

    Published on: February 8, 2017

    27.1K
    Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells10:01

    Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

    Published on: August 2, 2022

    7.0K

    相关概念视频

    Cadherins in Tissue Organization01:19

    Cadherins in Tissue Organization

    The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
    Cell Sorting During Development
    Cell sorting plays an...
    3.2K
    Metastasis02:30

    Metastasis

    Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
    Epithelial-to-Mesenchymal Transition
    The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
    5.7K
    Selectins01:25

    Selectins

    Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
    3.4K
    Structure of Cadherins01:25

    Structure of Cadherins

    The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
    3.6K
    Cancer Cell Migration through Invadopodia01:35

    Cancer Cell Migration through Invadopodia

    Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
    2.4K
    The Tumor Microenvironment02:17

    The Tumor Microenvironment

    Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
    6.8K