在位置导航过程中空间参考框架的皮层分离
Patrick A LaChance1, Elaina R Gross1, Shruthi Sankaranarayanan1
1Center for Systems Neuroscience and Department of Psychological and Brain Sciences, Boston University, Boston, MA 02215, USA.
bioRxiv : the preprint server for biology
|July 16, 2025
概括
后体内皮层 (POR) 和中体内体内皮层 (MEC) 不同地处理空间信息. POR神经元跟踪视觉地标,而MEC神经元保持一个全中心地图,揭示了空间导航中的关键分离.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 空间导航 空间导航
背景情况:
- 动物使用感官输入和记忆来导航相对于学习的位置.
- 感官刺激 (自我中心) 必须转化为一个非中心的框架,以实现目标导航.
- 假设从后内皮层 (POR) 到中枢内内皮层 (MEC) 的投射介导了这种自我中心-非中心的转变.
研究的目的:
- 调查POR和MEC在位置导航期间的空间表示的差异.
- 了解这两个大脑区域如何为将自我中心感官信息整合到一个非中心空间地图中做出贡献.
主要方法:
- 从POR和MEC记录了小鼠执行空间导航任务的单个神经元.
- 老鼠反复访问了一个熟悉的,未经培养的偏心位置,在一个开放的领域获得奖励.
- 视觉地标被操纵,以创建视觉场景和学习位置之间的冲突.
主要成果:
- 无论是POR还是MEC的神经元都显示出强烈的空间调,但这两个区域都没有偏向目标位置.
- 当视觉地标与已学习的位置发生冲突时,POR神经元会调整调整以遵循地标.
- MEC神经元保持了对全球参考框架的调整,保持与真正的偏心位置保持一致.
结论:
- 在导航过程中,POR和MEC空间参考框架之间存在显著的分离.
- POR神经元似乎代表着自我中心的视觉信息,而MEC神经元保持着一个全中心的空间地图.
- 这些发现引发了关于自我中心的POR信号如何被整合到MEC的全中心地图的问题.
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