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Updated: Sep 15, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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原生蛋白质复合体对向蛋白质降解的贡献

Lorraine Glennie1, Nicole Curnutt2, Tyrell Cartwright1

  • 1Medical Research Council Phosphorylation & Ubiquitylation Unit (MRC-PPU), School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK.

bioRxiv : the preprint server for biology
|July 16, 2025
PubMed
概括

向蛋白质降解 (TPD) 通过利用分子粘剂,在复合体内共同降解蛋白质. 这项研究表明,CK1α-SACK1复合体一起降解,突出了TPD策略中蛋白质背景的重要性.

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