在语言处理过程中异常高的连接性与患有自限性的儿童的认知表现不佳有关
bioRxiv : the preprint server for biology
|July 16, 2025
概括
带有中尖的自限性儿童 (SeLECTS) 在运动和语言区域之间增加了大脑连接. 这种异常的连接性与较差的语音意识有关,这表明中认知问题的新生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 儿科神经学 儿科神经学
- 认知科学 认知科学
背景情况:
- 带有中尖的自限性 (SeLECTS) 经常表现为语言障碍,尽管发作起源于运动区域.
- 这表明不同大脑网络之间的异常相互作用与认知缺陷有关.
研究的目的:
- 调查SELECTS儿童在语言任务期间的功能性大脑连接是否预测了他们的语言表现.
- 在儿科中识别语言功能障碍的潜在神经生物标志物.
主要方法:
- 使用高密度EEG记录SELECTS (n=31) 和对照组 (n=32) 的儿童在语言任务 (动词生成,重复) 和休息期间的脑活动.
- 功能连接测量使用权重相位滞后指数 (wPLI) 测量了运动和语言区域之间的功能连接.
- 用声学处理-2-2的综合测试来评估声学意识.
主要成果:
- 与对照组相比,SELECTS的儿童在语言处理过程中显示出运动和语言皮层之间的连接性明显更高.
- 在特定的语言任务中,在SELECTS中观察到较高的运动-前部和前部-部连接.
- 在语言任务中增加的半球间连接力与SELECTS儿童的语音意识较差有很强的相关性.
结论:
- 患有SELECTS的儿童在运动和语言网络之间表现出病理性增强的连接性,与语音意识受损有关.
- 异常的半球间连接被确定为SELECTS语言功能障碍的关键机制.
- 基于EEG的连接性测量表明,作为指导治疗儿科的认知障碍的生物标志物具有前途.
更多相关视频
09:57Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
2.8K
08:23A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
11.3K
相关概念视频
01:27Language and Cognition
450
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
450
01:24Epilepsy and Seizures: Overview
285
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
285
01:10Higher Mental Functions of the Brain: Language
1.0K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
1.0K
01:13Seizures: Classification
600
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
600