在上层中,多个神经元组将价值信号转化为动的活力
Atul Gopal1, Okihide Hikosaka1
1Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
bioRxiv : the preprint server for biology
|July 16, 2025
概括
价值信息通过调节上结膜 (SC) 中的神经活动来增强眼睛的运动. 神经元对高价值物体的反应促进了更快的冲动,一种新型的强力神经元可能有助于这一过程.
科学领域:
- 神经科学是一个神经科学.
- 眼神运动控制器的控制器
- 决策方式 决策方式
背景情况:
- 上层结肠 (SC) 对于控制眼睛运动 (动) 至关重要.
- 不同的SC神经元亚型在萨卡德生成中具有不同的作用.
- 基于价值的决策影响运动活力,但其在SC中的神经基础尚不清楚.
研究的目的:
- 研究价值信息如何调节SC神经元活动.
- 在SC神经元亚型中确定基于值的调制的时间动态.
- 识别神经机制背后的更快的冲刺到高价值的目标.
主要方法:
- 在子中同时记录四种SC神经元亚型.
- 子对与大 (好) 或小 (坏) 奖励相关的物体进行了冲刺.
- 引导分析用于识别神经元活动 (视觉和运动) 的不同时间阶段.
主要成果:
- 三种SC神经元亚型 (视觉,视觉运动,运动) 显示出对高价值物体的射击增加.
- 基于价值的调制发生在视觉晚期 (LVIS) 和前动 (PreSAC) 阶段,而不是视觉早期 (EVIS).
- 发现了一种新型的强化神经元类别,可以抑制活动,直到完成.
结论:
- 来自其他大脑区域的价值信息调节SC视觉和运动反应.
- 增强的LVIS和PreSAC活动促进了更快的saccade启动和执行.
- 性SC神经元可以通过消毒其他SC神经元相互作用来促进动.
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