人类新生儿下丘脑的基于MRI的结构发展
Elizabeth Yen1,2,3, Josepheen DeAsis-Cruz4,5, Jerod M Rasmussen6,7,8
1Tufts University School of Medicine, Boston, Massachusetts, USA.
bioRxiv : the preprint server for biology
|July 16, 2025
概括
像吸烟这样的产前暴露会影响新生儿的下丘脑体积. 这个大脑区域的大脑区域.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 宫内暴露可能会影响早期的下丘脑结构和未来的疾病风险.
- 有限的人类数据存在于产前因素对发展下丘脑的影响.
研究的目的:
- 调查新生儿产前暴露和下丘脑体积之间的关联.
- 为了检查诸如妊娠年龄,性别,母亲的BMI和吸烟等因素如何影响早期大脑发育.
主要方法:
- 利用了631名新生儿的T1加权MRI扫描,用于人类连接体的发展项目.
- 采用线性混合效应模型来分析与产前暴露的关联.
- 在青少年大脑和儿童发育研究 (ABCD) 中部分复制的发现.
主要成果:
- 下丘脑体积随月经后年龄增加,但当调整为大脑体积时不会增加.
- 男性的绝对下丘脑体积较大,但相对下丘脑体积较小.
- 较低的妊娠年龄与较大的相对下丘脑体积有关,其影响取决于性别.
- 产前吸烟与新生儿和青少年下丘脑体积较小有关.
结论:
- 下丘脑是围产期影响的敏感目标.
- 早期的下丘脑发育对于了解长期健康和疾病起源至关重要.
相关概念视频
Diencephalon: Hypothalamus and Coordination
2.2K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
2.2K
Magnetic Resonance Imaging
7.2K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
7.2K
Diencephalon: Anatomical Regions
2.9K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
2.9K
Anatomy of the Brain: Major Regions
6.6K
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
6.6K


