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Updated: Sep 15, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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Published on: December 3, 2020

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APOE4驱动肝脏蛋白质组的广泛变化,并改变代谢功能

Colton R Lysaker1,2, Chelsea N Johnson2,3, Vivien Csikos1,2

  • 1Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.

bioRxiv : the preprint server for biology
|July 16, 2025
PubMed
概括

阿波利波蛋白E4 (APOE4) 基因变体显著损害肝脏线粒体功能,并以性别特定的方式重新连接肝脏新陈代谢,影响葡萄糖和脂质处理.

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