早期的食物不安全性会在成年期损害记忆功能
Alicia E Kao1, Olivia P Moody1, Emily E Noble2
1Department of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, 3616 Trousdale Parkway, AHF-252, Los Angeles, CA 90089-0372, USA.
bioRxiv : the preprint server for biology
|July 16, 2025
概括
在老鼠早期的食物不安全性损害了依赖海马的记忆力,即使没有代谢变化. 这项研究强调了在发育过程中不可预测的食物获取的潜在长期神经认知影响.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 代谢研究研究 代谢研究
背景情况:
- 粮食不安全影响着数以百万计的人,但它的发育神经认知和代谢影响尚未得到充分理解.
- 生命早期的发展是大脑和代谢编程的关键窗口.
研究的目的:
- 研究早期食品不安全的长期神经认知和代谢后果.
- 建立一种新的老鼠模型,用于控制在发育过程中获得食物的时间,类型和数量.
主要方法:
- 用一个老鼠模型与三个组进行了测试:安全 (SC),安全混合 (SM) 和不安全混合 (IM).
- 不安全混合组在出生后的26-45天中经历了不可预测的食或高脂肪,高糖 (HFHS) 饮食在不同的热量水平.
- 成年后进行了代谢和行为评估,包括对焦虑,探索,冲动和记忆的测试.
主要成果:
- 在成年人热量摄入量,体重或身体组成方面,在各组之间没有发现显著差异.
- 行为测试显示,在焦虑类,探索性或冲动性行为方面没有群体差异.
- 与对照组相比,不安全混合组在海马体依赖的记忆功能方面表现出显著的损伤.
结论:
- 早期的食物不安全,即使没有代谢障碍,也可能导致记忆功能的持久损害.
- 这项研究提供了在关键发育时期不可预测的食物获取和长期认知缺陷之间的联系的证据.
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