同时的孕产妇压力和怀孕期间的THC暴露会改变青少年的行为结果和皮质膜分子程序
Jimmy Olusakin1, Mahima Dewan2, Atul Kashyap3
1Department of Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland.
bioRxiv : the preprint server for biology
|July 16, 2025
概括
产前接触大麻 (THC) 和压力会影响母亲的行为和后代的神经发育. 这些影响是附加的,影响焦虑,动机和社会行为,在大脑中产生持久的分子变化.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 怀孕期间大麻的使用量正在上升,通常用于减轻压力.
- 产前大麻暴露和压力对后代神经发育的长期影响尚不清楚.
研究的目的:
- 调查产前THC暴露和心理社会压力对母亲行为和后代神经发育的综合影响.
- 为了确定与这些暴露相关的后代大脑中的分子变化.
主要方法:
- 使用一种动物模型,将怀孕的小鼠暴露在慢性心理社会压力 (母亲的证人失败压力) 和每日THC或车辆中.
- 评估了母亲的行为,产后结果和青少年后代的行为.
- 进行了前额叶皮和核的转录形状分析.
主要成果:
- THC和压力都影响了母亲的行为,在组合组中增加了负面影响.
- 后代表现出暴露特异性的行为变化,包括增加焦虑和减少动机.
- 转录组分析揭示了与线粒体功能,突触组织和质信号传递相关的明显的,性别和区域特定的基因表达变化.
结论:
- 产前THC和压力独立和附加地损害了母亲的护理,并导致后代的长期神经发育变化.
- 每次暴露都会影响不同的分子通路,其中一些目标与其他围产期暴露 (如芬太尼) 共享.
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