在自闭症谱系障碍中,前带带皮折叠模式发生变化
Ethan H Willbrand1,2, Samira A Maboudian3,4, Jacob J Ludwig1
1School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI USA.
bioRxiv : the preprint server for biology
|July 16, 2025
概括
神经类型的男性比自闭症谱系障碍 (ASD) 的男性表现出更不对称的状硫模式. 这表明ASD年轻男性前带带皮质 (ACC) 中产前神经发育差异.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 自闭症谱系障碍研究研究
背景情况:
- 大脑皮层的焦点差异,特别是形模式,在自闭症谱系障碍 (ASD) 中被观察到.
- 前带带皮质 (ACC) 在社会认知和执行功能中起着至关重要的作用,这些区域在ASD中经常受到影响.
研究的目的:
- 首次研究ASD年轻男性中与神经类型 (NT) 个体相比,ACC的状模式和形态.
- 为了检查ACC内部的半球 (PCGS) 的存在和半球不对称性.
主要方法:
- 利用来自50名NT和50名年龄相匹配的20岁以下男性参与者的神经成像数据.
- 使用FreeSurfer软件从T1加权的MRI扫描中生成皮质重建.
- 确定和量化了PCGS的存在,不对称性,长度,深度和皮质厚度.
主要成果:
- 与ASD参与者相比,神经类型参与者表现出不对称的PCGS模式的可能性显著更高.
- 在PCGS的定量形态特征 (长度,深度,皮层厚度) 中,在两组之间没有发现显著差异.
- 结果对年龄和扫描器位置进行了控制.
结论:
- 研究结果表明,在患有自闭症的年轻男性中,ACC的产前神经发育有变化,特别是关于PCGS不对称性.
- 观察到的PCGS模式差异可能代表一个潜在的特征标记,需要进一步调查其在ASD病原体中的作用.
- 增加了文献,表明PCGS变异作为多种神经发育障碍的潜在标志物.
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