预后营养指数作为败血症患者预后的潜在预测指标:一个回顾性队列研究

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Mingyuan Pan¹, Zheng Li², Shanfeng Sheng²

¹The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Frontiers in nutrition

|July 16, 2025

概括

预后营养指数 (PNI) 是一个有价值的,简单的指标,用于预测败血症死亡风险. 较高的PNI水平与重症患者中较低的短期和中期死亡率相关.

科学领域:

关键护理医学关键护理医学
营养科学营养科学
预测生物标志物预测生物标志物

背景情况:

败血症是重症患者的主要死亡原因,常常由免疫功能障碍和营养不良复杂化.
目前存在的败血症预后生物标志物往往复杂且难以临床应用.
预后营养指数 (PNI) 为评估败血症预后提供了一个潜在的更简单的替代方案.

研究的目的:

评估预后营养指数 (PNI) 在败血症患者的预后潜力.
确定PNI与败血症全因死亡率之间的关联.
确定用于预测死亡风险的关键PNI值.

主要方法:

对6234名进入ICU的败血症患者 (2008-2022) 的回顾性分析.
在入院后24小时内计算PNI.
使用卡普兰-梅尔分析,多变量考克斯回归,限制立方线 (RCS) 和ROC分析来评估PNI与死亡率的关联.

主要成果:

较高的PNI与较低的14日,28日和90日全因死亡率显著相关 (HRs < 0.60,P < 0.0001).
RCS分析显示,PNI和死亡率之间存在非线性关系,并确定了拐点.
虽然PNI的预测值低于SOFA/APACHE II,但可以提高其预测能力.

结论:

PNI与败血症患者的短期和中期全因死亡率有显著的关联.
PNI作为一个有价值和可访问的指标,用于预测感染性败血症的住院和ICU死亡风险.
这些发现支持PNI在败血症患者管理中的临床实用性.

关键词:

专辑蛋白 (albumin) 是一种淋巴细胞淋巴细胞.死亡率死亡率预后预后预后预后营养指数的预后.这是一种血症.

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