在状细胞癌重建中,术后血管危机的危险因素是使用超关节动脉片重建状细胞癌
Peipei Sun1, Mingzhe Zhao2, Hanying Tang3
1Department of Stomatology, Central Hospital Affiliated to Shandong First Medical University Jinan 250000, Shandong, China.
American journal of cancer research
|July 16, 2025
概括
鉴定头部和部状细胞癌 (SCC) 的大关动脉膜重建后血管危机的危险因素至关重要. 在手术前优化诸如BMI,吸烟,酒精,血糖,CRP,WBC和SCC抗原等因素可以提高片生存率.
科学领域:
- 头部和部手术 头部和部手术
- 手术瘤学手术瘤学
- 血管外科 血管外科
背景情况:
- 舌头和口腔粘膜的状细胞癌 (SCC) 通常需要复杂的重建.
- 超关节动脉被用于重建,但血管危机仍然是一个并发症.
- 识别血管危机的危险因素对于改善患者的治疗结果至关重要.
研究的目的:
- 确定手术后血管危机的独立风险因素,在接受舌头和口腔SCC的上关节动脉片重建的患者中.
- 开发血管危机的预测模型,以指导术前优化.
主要方法:
- 对777名患有舌头或口腔SCC的患者进行了回顾性分析,这些患者正在接受超关节动脉片重建.
- 在患有血管危机和没有血管危机的患者之间比较人口统计学,临床,血液学和生物化学参数.
- 多变量物流回归和ROC曲线分析以确定风险因素并开发预测模型.
主要成果:
- 血管危机的独立风险因素包括更高的BMI,长期吸烟,长期饮酒,高血糖,高C反应蛋白,高白细胞计数和高SCC抗原 (所有P<0.05).
- 血小板计数与风险相反相关.
- 预测模型显示出强大的区分能力 (AUC = 0.975),在血管危机组的板存活率显著降低.
结论:
- 可修改的临床和生化因素与术后血管危机有显著的关联.
- 在SCC重建中,对已识别的风险因素进行手术前优化可能会提高片存活率和整体手术结果.
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