用第三代表皮生长因子受体-铁氨酸激酶抑制剂治疗的非小细胞肺癌的抵抗模式

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Updated: Sep 15, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Published on: June 26, 2019

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Nana Chen1,2, Feng Zhao1,2, Lu Yang1,2

  • 1Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute Jinan, Shandong, China.

American journal of cancer research
|July 16, 2025
PubMed
概括

第三代EGFR-TKIs对EGFR突变NSCLC有效,但面临耐药性. 超过50%的患者经历了原始部位衰竭,受性别,中枢神经系统转移和疾病阶段的影响.

关键词:
欧洲农业基金-土耳其.非小细胞肺癌是非小细胞肺癌.阻力模式 阻力模式

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