IL-33作为COPD疾病严重程度的生物标志物与肺癌并发症
Hui Ren1, Yan Cui2, Xiuyun Lv1
1Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Inner Mongolia Medical University Hohhot 010059, Inner Mongolia Autonomous Region, China.
American journal of cancer research
|July 16, 2025
概括
在患有并发性慢性阻塞性肺病 (COPD) 和肺癌的患者中,介素-33 (IL-33) 含量显著升高. 较高的IL-33水平与肺功能减弱和疾病严重程度增加相关,表明其作为生物标志物的潜力.
科学领域:
- 肺病学和瘤学 在
- 免疫学和炎症 免疫学和炎症
背景情况:
- 慢性阻塞性肺病 (COPD) 和肺癌往往并存,带来复杂的临床挑战.
- 炎症性细胞因子在COPD和肺癌的发病过程中起着至关重要的作用.
研究的目的:
- 为了比较COPD和肺癌并发症患者与单独COPD患者之间的外周血液中互白素-1β (IL-1β),IL-6,IL-17和IL-33的水平.
- 研究这些炎症性细胞因子在区分两个患者群体的临床意义和潜在生物标志物.
主要方法:
- 与酶相关的免疫吸收试验 (ELISA) 用于测量同伴性COPD和肺癌的133名患者和单独患有COPD的91名患者的IL-1β,IL-6,IL-17和IL-33的血清水平.
- 进行了统计分析,包括多变量逻辑回归,以确定与并发症相关的差异和独立因素.
主要成果:
- 与单独患有COPD的患者相比,患有并发性COPD和肺癌的患者表现出明显更高的IL-33水平.
- 在COPD组中,IL-33水平与肺功能参数 (FEV1,FVC,FEV1/FVC,RV,RV/TLC) 呈负相关,与GOLD分期呈正相关.
- 多变量分析确定了IL-33,吸烟史,GOLD分期和肺功能参数作为独立的因素,区分并发症患者.
结论:
- 升高的IL-33水平是伴随性COPD和肺癌患者的重要指标.
- IL-33显示出作为评估疾病严重程度和区分COPD患者的并发性疾病的有价值生物标志物的潜力.
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