通过全基因组CRISPR/Cas9图书馆查,确定β4GALNT2作为抗hPIV3因子

Xuesheng Wu1, Rutger D Luteijn1, Estefanía Lozano-Andrés2,3

  • 1Section Virology, Division Infectious Diseases and Immunology, Department Biomolecular Health Sciences, Faculty Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

PubMed
概括

人类类类型流感病毒3 (hPIV3) 导致严重的呼吸道感染. 研究人员发现,酶β4GALNT2通过改变细胞表面甘氨酸来限制hPIV3,阻断病毒的附着和感染.