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基于的生物材料作为癌症放射治疗的有希望的工具

Qian Wang¹, Xinhui Chu¹, Jianfeng Liu¹

¹State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|July 16, 2025

概括

基于的生物材料通过改善瘤向和减少副作用来增强癌症放射治疗. 本综述涵盖用于先进辐射疗法 (RT) 策略的类放射敏感剂和放射性药物.

科学领域:

生物材料科学生物材料科学
在瘤学瘤学.
放射化学放射化学是指辐射化学.

背景情况:

放射治疗 (RT) 是一种至关重要的癌症治疗方法,但选择性地破坏瘤,同时保留健康的组织是具有挑战性的.
生物材料提供了一种有前途的方法来提高RT的有效性并最大限度地减少副作用.
基于的生物材料因其在RT应用中的独特特性而受到关注.

研究的目的:

审查基生物材料在瘤放射治疗中的使用.
探索使用放射性药物的新兴放射敏感方法和RT策略.
引入基于的放射性敏感剂和放射性药物.

主要方法:

在RT中对基生物材料的文献综述.
基于的放射敏感剂的分类 (直接,载体,向).
-放射性核酸结合物 (PRCs) 的分析,包括临床数据.

主要成果:

基于的生物材料提供了诸如可控合成,生物相容性,向性和自我组装等优势.
基于的放射敏感剂被分为三个主要类型.
基于的放射性药物 (PRC) 按标被分类,并提供临床示例.

结论:

基于的生物材料显示出优化放射治疗的巨大潜力.
考虑生物材料特性的合理设计是有效的RT策略的关键.
这些先进的RT工具在临床转化方面的挑战需要进一步研究.

关键词:

基于的生物材料.放射性药物制品放射性药物制品无线电敏感化剂的使用.辐射疗法辐射疗法

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