11α-hydroxydysobinin:一种来自Chisocheton macrophyllus种子 (Meliaceae) 的新型类物质
1, Lulu Wilden Azzahra1, Wahyu Safriansyah1
1Natural Products Chemistry and Synthesis Laboratory, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Journal of Asian natural products research
|July 16, 2025
概括
研究人员从Chisocheton macrophyllus种子中分离出了一个新的limonoid,11α-hydroxydisobinin. 这种化合物和另一种已知的利蒙体对乳腺癌细胞表现出细胞毒性.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 有机化学 有机化学
背景情况:
- 奇索切顿巨种子是生物活性天然产品的潜在来源.
- 类是类的一类,具有多样化的生物活动.
研究的目的:
- 从Chisocheton macrophyllus种子中分离和描述新的化合物.
- 为了评估孤立的limonoids对乳腺癌细胞的细胞毒性潜力.
主要方法:
- 使用溶剂提取的化合物的隔离.
- 使用高分辨率电子喷雾电离质谱法 (HR-ESI-MS),紫外线,红外线,核磁共振 (NMR) 和电子循环二元化 (ECD) 分析进行结构阐明.
- 对MCF-7乳腺癌细胞的细胞毒性测定.
主要成果:
- 一个新的limonoid,11α-hydroxydisobinin (1),被分离和表征.
- 一种已知的limonoid (2) 也被分离出来.
- 化合物1对MCF-7细胞的IC50值为112.5μM.
- 化合物2对MCF-7细胞具有更强的活性,IC50值为51.7μM.
结论:
- 11α-hydroxydisobinin是一种新型的limonoid,从Chisocheton macrophyllus中分离出来.
- 隔离的limonoids对乳腺癌细胞具有细胞毒性,这表明进一步药物开发的潜力.
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