饮食中的铁可以通过调节肠道免疫反应和肠道微生物群来减弱Clostridioides difficile感染
Xiao Li1, Xiaoxiao Wu1, Wanqing Zang1
1Xuzhou Key Laboratory of Laboratory Diagnostics, School of Medical Technology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
高食铁可以通过改变肠道微生物群和减少病原体毒性来缓解Clostridioides difficile感染 (CDI). 这种饮食干预促进肠道平衡,并可能为CDI管理提供一种新的策略.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 艰难菌感染 (CDI) 是与抗生素相关的腹的一个重要原因.
- 肠道微生物群的组成和饮食极大地影响宿主对CDI的易感性.
- 连接饮食,微生物群和CDI病变的机制尚未完全理解.
研究的目的:
- 为了研究高铁饮食对肠道免疫,微生物群和新陈代谢在CDI小鼠模型的影响.
- 在高铁条件下阐明特定肠道微生物群和代谢物在CDI中的作用.
主要方法:
- 建立了CDI的小鼠模型,有或没有高食铁 (400毫克/公斤硫酸铁).
- 使用16S rRNA基因测序分析了肠道微生物群的变化.
- 便微生物群移植 (FMT) 被用于确认肠道微生物群的作用.
主要成果:
- 高食铁减轻了CDI的严重性,通过减少C. difficile的致病性和减少中性粒细胞的招募.
- 在铁处理小鼠的肠道微生物群中丰富大肠杆菌AVS0501对CDI提供了预防和治疗的好处.
- 在接受铁治疗的小鼠中,升高的L-proline和tauroursodeoxycholic acid (TUDCA) 水平调节了C. difficile殖民,毒素产生和宿主免疫反应.
结论:
- 饮食中大量摄入铁可以通过调节肠道微生物群和维持肠道平衡来改善C. difficile诱导的肠炎.
- 特定的微生物代谢物L-proline和TUDCA在高食铁的保护作用中起作用.
- 饮食中的铁是控制CDI的潜在决定因素.
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