Jove
Visualize
联系我们

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Comparative analysis of structural modifications induced by monocular retinal inactivation and monocular deprivation in the developing cat lateral geniculate nucleus.

The Journal of comparative neurology·2023
Same author

Activating parvalbumin-expressing interneurons produces iceberg effects in mouse primary visual cortex neurons.

Neuroscience letters·2022
Same author

Optogenetic Activation of Interneuron Subtypes Modulates Visual Contrast Responses of Mouse V1 Neurons.

Cerebral cortex (New York, N.Y. : 1991)·2021
Same author

Modification of Peak Plasticity Induced by Brief Dark Exposure.

Neural plasticity·2019
Same author

Fast Recovery of the Amblyopic Eye Acuity of Kittens following Brief Exposure to Total Darkness Depends on the Fellow Eye.

Neural plasticity·2019
Same author

Month-long cardiac surgery boot camp: A proposal to jumpstart resident training.

The Journal of thoracic and cardiovascular surgery·2018
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Sep 15, 2025

Injections of AAV Vectors for Optogenetics in Anesthetized and Awake Behaving Non-Human Primate Brain
09:42

Injections of AAV Vectors for Optogenetics in Anesthetized and Awake Behaving Non-Human Primate Brain

Published on: August 4, 2021

3.7K

在麻醉小鼠初级视觉皮层中表征光遗传介导的反弹效应.

Jared T Shapiro1, Nicole M Michaud1, Nathan A Crowder1

  • 1Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.

The Journal of physiology
|July 16, 2025
PubMed
概括

鼠标视觉皮层的后抑制性反弹被强烈的视觉刺激放大,并根据内部神经元类型而异. 这项研究探讨了网络活动如何影响皮质电路中的反弹效应.

科学领域:

  • 神经科学是一个神经科学.
  • 计算神经科学是一种神经科学.
  • 系统神经科学 系统神经科学

背景情况:

  • 光遗传工具使得神经回路的研究成为可能,特别是在小鼠的初级视觉皮层 (V1).
  • 抑制性内部神经元亚型 (parvalbumin+, somatostatin+,血管活性肠+) 的光刺激可以调节刺激性金字塔神经元反应.
  • 之前的研究指出,光刺激后的反弹升,但缺乏系统分析.

研究的目的:

  • 在V1金字塔细胞和内部神经元中系统地描述光遗传介导的反弹效应.
  • 调查V1网络活动和连接性对反弹幅度的影响.
  • 为了比较刺激不同内部神经元亚型引起的反弹效应.

主要方法:

  • 在麻醉小鼠中对帕瓦尔胺 (Pvalb+),索马托斯塔丁 (SOM+) 和血管活性肠 (VIP+) 内神经元进行光遗传光刺激.
  • 在金字塔细胞和内部神经元中记录反弹效应.
  • 反弹幅度与视觉刺激强度和网络活动的相关性.

主要成果:

  • 当内部神经元光刺激与V1.1强烈的视觉激活相吻合时,反弹效应最大.
  • 直接刺激的内部神经元表现出不同于反弹的极性和时间的激活后效应.
关键词:
电力生理学 电力生理学内部神经元内部神经元神经电路的神经电路.在抑制后的反弹效应.转基因小鼠的转基因小鼠

更多相关视频

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse
05:50

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Published on: February 12, 2020

13.7K
Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits
07:43

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

Published on: December 27, 2013

9.3K

相关实验视频

Last Updated: Sep 15, 2025

Injections of AAV Vectors for Optogenetics in Anesthetized and Awake Behaving Non-Human Primate Brain
09:42

Injections of AAV Vectors for Optogenetics in Anesthetized and Awake Behaving Non-Human Primate Brain

Published on: August 4, 2021

3.7K
Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse
05:50

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Published on: February 12, 2020

13.7K
Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits
07:43

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

Published on: December 27, 2013

9.3K
  • 对Pvalb+内部神经元的光刺激产生了最显著的反弹效应.

    • 结论:

    • 细胞和网络机制都会导致小鼠V1.1中的反弹效应.
    • 视觉皮层激活水平调节了抑制后反弹幅度.
    • 不同的内部神经元亚型产生不同的反弹特征,为激发-抑制平衡提供了洞察力.