心血管风险,健康指标和癌症预测:一个全面的综述
Gretell Henriquez-Santos1, Ji-Eun Kim2, Sant J Kumar3
1Heart Disease Phenomics Laboratory, Epidemiology and Community Health Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
JACC. CardioOncology
|July 16, 2025
概括
较高的心血管疾病 (CVD) 风险得分和较差的心血管健康 (CVH) 指标与癌症风险增加有关. 相反,理想的CVH指标与患癌症的风险降低有关.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 心血管疾病 (CVD) 和癌症是全球主要的死亡原因.
- 共同的风险因素表明,心血管疾病风险评估工具与癌症发病率之间存在潜在联系.
研究的目的:
- 系统地审查和总结研究,调查CVD风险得分,CVH指标和癌症发病率之间的关联.
- 确定已确定的心血管疾病风险因素是否可以预测癌症的发展.
主要方法:
- 在2024年4月,对四个主要数据库 (Embase,PubMed,Scopus,Web of Science:Core) 进行了全面的系统搜索.
- 来自13项符合条件的前性研究的数据,涉及18岁及以上的成年人,由五位审查员独立选和提取.
- 研究的重点是癌症发病率作为结果和心血管疾病风险得分或CVH指标作为暴露.
主要成果:
- 该审查包括13项研究,检查了14个心血管或心血管和心血管疾病指标,样本大小从1,880到342,226名参与者.
- 较高的动脉样硬化心血管疾病风险得分始终与癌症发病率的增加有关 (危险比:1.163.71).
- 理想的心血管健康指标,如美国心脏协会的Life's Simple 7,与癌症风险降低有关 (危险比:0.490.95).
结论:
- 大多数纳入的研究表明,较差的心血管疾病风险得分和低于最佳的CVH指标预测患癌症的风险更高.
- 尽管指标和癌症类型不同,但研究结果支持心血管健康和癌症风险之间的联系.
- 未来的研究应该集中在特定的CVD风险指标和癌症类型上,以实现元分析和完善预测模型.
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