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相关概念视频

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Niche01:26

Stem Cell Niche

5.3K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.3K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.3K

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相关实验视频

Updated: Sep 15, 2025

Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell MSC Spheroids Primed in 3-D Cultures Under Xeno-free Conditions
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Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell MSC Spheroids Primed in 3-D Cultures Under Xeno-free Conditions

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介质细胞 stromal 细胞:一个更新

Olivia J Lee1,2,3, Armand Keating1,2,4,3

  • 1Krembil Research Institute.

Current opinion in hematology
|July 16, 2025
PubMed
概括

介质细胞 stromal 细胞 (MSCs) 显示治疗承诺,特别是在COVID-19 ARDS. 了解MSC生物学和标准化的进展是改善临床结果和再生医学应用的关键.

科学领域:

  • 再生医学是一种再生医学.
  • 细胞生物学 细胞生物学
  • 免疫学 免疫学 免疫学

背景情况:

  • 介质细胞层细胞 (MSCs) 在1500多项临床试验中得到了广泛的研究.
  • MSC的应用包括治疗COVID-19相关急性呼吸系统应急综合征 (ARDS) 等疾病.

研究的目的:

  • 为了回顾最近在介质细胞 (MSC) 生物学上的进展.
  • 巩固对MSC作用机制和临床实用性的理解.
  • 突出MSC免疫调节和治疗应用方面的进展.

主要方法:

  • 综述最近的科学文献关于中介细胞 stromal 细胞 (MSC) 生物学和临床研究.
  • 关于MSC异质性的单细胞分析结果的分析.
  • 检查对中介细胞 stromal cell (MSC) 功效测试的监管更新.

主要成果:

  • 最近的进展包括了解MSC免疫调节机制,其中包括microRNA和长非编码RNA.
  • 对于COVID-19 ARDS,MSC疗法表现有前景,已经批准了几种产品.
  • 单细胞分析显示MSC异质性,受细胞外基质的影响.
  • 美国食品和药物管理局的建议强调全面的质量控制和需要一个普遍的介质细胞 (MSC) 参考标准.
关键词:
临床试验是指临床试验中的临床试验.不同质性的异质性免疫调节的免疫调节介质细胞干细胞介质细胞干细胞实力测试试验 实力测试试验

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Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
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Last Updated: Sep 15, 2025

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Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell MSC Spheroids Primed in 3-D Cultures Under Xeno-free Conditions

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Purification, Expansion, and Flow Cytometry-Based Phenotyping of Mouse Derived Bone Marrow Mesenchymal Stem Cells
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Purification, Expansion, and Flow Cytometry-Based Phenotyping of Mouse Derived Bone Marrow Mesenchymal Stem Cells

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Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
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Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications

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结论:

  • 介酶体 stromal 细胞 (MSCs) 具有显著的治疗潜力.
  • 解决介质细胞 stromal cell (MSC) 异质性和标准化功效对于临床成功至关重要.
  • 了解介质细胞 (MSC) 免疫特性和应用的进步将改进它们在再生医学中的应用.