在患有自身免疫性风湿性疾病的患者中重新分类动脉硬和心血管风险
Albertina M Ghelfi1,2,3, Rosana Quintana4,5, Lautaro L Velez6,4
1Unidad de Hipertensión Arterial y Riesgo Cardiovascular, Hospital Escuela Eva Perón. Granadero Baigorria, Santa Fe, Argentina. albertinaghelfi@hotmail.com.
概括
在临床缓解期的自身免疫性风湿性疾病患者仍然表现出动脉硬度和脉冲波速度的增加,这表明早期的血管损伤. 即使心血管风险较低,这种情况也会发生,这凸显了对这些人血管健康的监测的必要性.
科学领域:
- 心血管医学 心血管医学
- 类风湿病学 类风湿病学
- 血管生物学 血管生物学
背景情况:
- 自身免疫性风湿性疾病 (ARD) 与亚临床血管损伤和动脉硬 (AS) 的风险增加有关.
- 目前尚不清楚这种血管损伤是否会在临床缓解或低疾病活性 (CR/LDA) 期间持续存在.
研究的目的:
- 在经历CR/LDA的ARD患者中评估带-关节脉冲波速率 (cf-PWV).
- 将ARD患者的cf-PWV与健康的对照组进行比较.
主要方法:
- 在阿根廷 (2022-2023) 进行的一项横截面研究,包括CR/LDA中的48名ARD患者和49名健康对照.
- 排除标准包括全身器官干扰,高血压和高心血管风险.
- 使用大动脉装置测量了带-大腿脉冲波速率 (cf-PWV).
主要成果:
- 与对照组相比,CR/LDA中ARD患者的cf-PWV显著更高,无论是高正常血压 (6.81±1.14对比5.98±0.82米/秒) 或正常血压 (6.57±1.09对比5.84±0.65米/秒) 的患者.
- 动脉硬性在ARD患者 (22/48高正常血压,14/36正常血压) 和对照组 (分别为2/49和0/37) 中更为普遍.
- 多变量分析确定了ARD和透气血压作为动脉硬的独立预测因素.
结论:
- 在CR/LDA中,自身免疫性风湿性疾病患者表现出升高的cf-PWV,表明持续的早期血管损伤.
- 这种增加的血管硬性甚至存在于传统上心血管风险较低的ARD患者中.
- 这些发现强调了评估ARD患者的血管健康的重要性,无论疾病活动或传统风险因素如何.
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