在没有肌肉骨干涉的牛皮患者中发生的亚临床综合炎:系统性审查和元分析
Shanti Mehta1, Grace Xiong2, Dea Metko2
1Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
JAMA dermatology
|July 16, 2025
概括
亚临床突炎在没有肌肉骨问题的牛皮病患者中比在健康个体中更为常见. 医学成像可以帮助识别那些有患上牛皮关节炎的风险的人.
科学领域:
- 类风湿病学 类风湿病学
- 皮肤病学 皮肤病学
- 医疗成像医学成像
背景情况:
- 牛皮影响着高达3%的人口,其中30%的人患有牛皮关节炎 (PsA).
- 从牛皮到PsA的过渡还没有完全理解.
- 亚临床综合炎在PsA之前,在没有肌肉骨症状的牛皮患者中可以通过成像检测到牛皮.
研究的目的:
- 用超声波和MRI在没有肌肉骨干涉的牛皮病患者中确定鼻膜炎的患病率.
- 将这些发现与健康对照组和被诊断患有PsA的患者进行比较.
主要方法:
- 在主要数据库 (MEDLINE,Embase,Scopus,Web of Science) 进行了系统的文献搜索,直到2024年10月.
- 涉及2606名患者的12项研究 (1593名牛皮,327名PsA,686名对照) 符合纳入标准.
- 一个随机效应模型被用于元分析,以组合膜炎流行率的风险比率.
主要成果:
- 与对照人群相比,牛皮患者的内膜炎的可能性是牛皮患者的2.55倍.
- 磁力共振成像检测到鼻膜炎的频率更高 (RR 6.40),而不是超声波 (RR 2.50).
- 炎在PsA患者中比牛皮患者更频繁,尽管在统计学上没有显著性 (RR 0.50).
结论:
- 与健康个体相比,在没有肌肉骨症状的牛皮患者中,亚临床肌炎的患病率明显高.
- 医学成像可以识别患有牛皮的个体,他们可能面临更高的风险发展为牛皮性关节炎.
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