德国代谢功能障碍相关的脂肪肝炎诊断和管理:专家共识小组的见解
Yestle Kim1, Peter Rydqvist1, Thomas Ramezani1
1Health Economics and Outcomes Research, Madrigal Pharmaceuticals Inc, West Conshohocken, Pennsylvania, USA.
概括
在德国,大约75%的代谢功能障碍相关的脂肪肝炎 (MASH) 患者没有被诊断出来. 专家建议改变生活方式和进行非侵入性测试,因为缺乏已批准的MASH治疗方法.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是慢性肝病的主要原因.
- 代谢功能障碍相关的脂肪肝炎 (MASH),是一种渐进的MASLD形式,可以导致纤维化和肝硬化.
- 预计到2030年,德国的MASH发病率将翻一番,这将带来重大诊断和管理挑战.
研究的目的:
- 为了在德国就MASH的诊断途径达成专家共识.
- 在德国背景下评估MASH目前的治疗方法.
主要方法:
- 一个为期三轮的Delphi小组调查,从2024年2月到5月在线进行.
- 涉及德国12名胃肠病学,糖尿病学和/或肝病学专家.
- 使用了与Delphi方法集成的标准调查来达成共识.
主要成果:
- 在德国,大约75%的MASH患者仍未被诊断出来.
- 非侵入性测量 (纤维化得分,肝酶,肝硬度) 是主要的诊断和监测工具.
- 改变生活方式是主要的管理策略;缺乏经批准的药理疗法.
结论:
- 德国MASH的实质性低诊断需要加强查和早期检测.
- 由于没有批准的治疗方法,依赖非侵入性诊断和生活方式的改变至关重要.
- 标准化算法和改善并发病的管理对于更好的患者结果至关重要.
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